The flow of cerebrospinal fluid (CSF) plays an important role in the clearance of waste from the brain. CSF flow alterations may contribute to the development and/or progression of some neurological diseases. We investigated CSF clearance from the lateral ventricles in Alzheimer’s disease, mild cognitive impairment, multiple sclerosis, and matched healthy controls using dynamic 11C-PIB PET. Compartmental modelling analysis was used to further understand the tracer kinetics in the lateral ventricles and better interpret our PET results. Together, our PET and compartmental modelling results indicate that CSF-mediated clearance is reduced in Alzheimer’s disease and multiple sclerosis compared to healthy controls.

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Credits: Julia Schubert, NRM2018, London.

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